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isoniazid will improve the level or effect of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Prevent coadministration of pazopanib with strong CYP3A4 inhibitors if possible; if ought to coadminister, minimize pazopanib dose to four hundred mg/working daypazopanib will boost the level or outcome of ruxolitin